7β-[(Z)-2-(2-AMinothiazol-4-yl)-2-(1-carboxy-1-MethylethoxyiMino)acetaMido]-3-acetoxyMethyl-3-cepheM-4-carboxylic Acid

Base Information

• Chemical Name: 7β-[(Z)-2-(2-AMinothiazol-4-yl)-2-(1-carboxy-1-MethylethoxyiMino)acetaMido]-3-acetoxyMethyl-3-cepheM-4-carboxylic Acid
• CAS No.: 73443-60-4
• Molecular Formula: C₁₉H₂₁N₅O₉S₂
• Molecular Weight: 527.536
• Mol file: 73443-60-4.mol

Synonyms:

Chemical Property of 7β-[(Z)-2-(2-AMinothiazol-4-yl)-2-(1-carboxy-1-MethylethoxyiMino)acetaMido]-3-acetoxyMethyl-3-cepheM-4-carboxylic Acid

Chemical Property:

• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Dimethylsulfoxide

Purity/Quality:

7β-[(Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-acetoxymethyl-3-cephem-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Uses: Cefotaxime (C242950) derivative, with antibacterial activity.

Technology Process of 7β-[(Z)-2-(2-AMinothiazol-4-yl)-2-(1-carboxy-1-MethylethoxyiMino)acetaMido]-3-acetoxyMethyl-3-cepheM-4-carboxylic Acid

There total 13 articles about 7β-[(Z)-2-(2-AMinothiazol-4-yl)-2-(1-carboxy-1-MethylethoxyiMino)acetaMido]-3-acetoxyMethyl-3-cepheM-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-1-tert-butoxycarbonyl-1-methyl-ethoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (263154-28-5) → acide (acetoxy methyl)-3(<<(carboxy-1 methyl-1 ethoxy)-imino-2 Z (amino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 (73443-60-4)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; for 2.5h;

DOI:10.1016/S0968-0896(99)00261-8

Reference yield: 72.0%

→ acide (acetoxy methyl)-3(<<(carboxy-1 methyl-1 ethoxy)-imino-2 Z (amino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 (73443-60-4)

Guidance literature:

Reference yield: 31.0%

→ (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-[(1-amino-1,2,3-triazol-3-ium)methyl]-ceph-3-em-4-carboxylate + acide (acetoxy methyl)-3(<<(carboxy-1 methyl-1 ethoxy)-imino-2 Z (amino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 (73443-60-4)

Guidance literature:

upstream raw materials:

ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4

(6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-1-tert-butoxycarbonyl-1-methyl-ethoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

benzhydryl 7-aminocephalosporanate

7-Aminocephalosporanic acid

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