(+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

Base Information

Chemical Name:(+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide
CAS No.:135522-12-2
Molecular Formula:C₂₁H₂₈Cl₂N₂O
Molecular Weight:395.372
Hs Code.:

(+/-)-N-methyl-N-<trans-2-(1-pyrrolidynyl)cyclohexyl>-1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

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Chemical Property of (+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

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Technology Process of (+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

There total 9 articles about (+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 342386-78-1
1-(3,4-dichlorophenyl)cyclopropanecarboxylic acid

: 67198-34-9,67198-53-2,67347-43-7,99239-39-1,116301-06-5,121843-49-0,121843-50-3,121843-51-4,142434-12-6
trans-(+/-)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine

: 135522-12-2
(+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

Guidance literature:: With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 4 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1002/cmdc.201100278

Reference yield:

: 69420-67-3
(+/-)-trans-[2-(pyrrolidinyl)]cyclohexanol

: 135522-12-2
(+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: tetrahydrofuran; H₂O / 18 h / Heating

3: Et₃N / CH₂Cl₂ / 2 h / 1.) 0 deg C, 2.) RT, 2 h

With triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0223-5234(91)90021-E

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 135522-12-2
(+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / H₂O / 28 h / 70 - 90 °C

2: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: tetrahydrofuran; H₂O / 18 h / Heating

4: Et₃N / CH₂Cl₂ / 2 h / 1.) 0 deg C, 2.) RT, 2 h

With water; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0223-5234(91)90021-E