3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

Base Information

Chemical Name:3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine
CAS No.:141733-86-0
Molecular Formula:C₄₀H₃₆ClN₅O₄S
Molecular Weight:718.276
Hs Code.:

3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

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Chemical Property of 3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

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Technology Process of 3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

There total 17 articles about 3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 141733-86-0
3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

Guidance literature:: Multi-step reaction with 12 steps

1: 0.5 h / 110 °C

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, from -70 deg C to -50 deg C, 30 min, 2.) CH₂Cl₂, from -50 deg C to RT

3: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

4: 247 g / CHCl₃ / Ambient temperature

5: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

6: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

7: Et₃N / toluene / Heating

8: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 1.5 h / 80 °C

9: 37 percent / dioxane / 2 h / 130 °C

10: 58 percent / TFA / CHCl₃ / 0 °C

11: pyridinium dichromate (PDC) / dimethylformamide / 15 h / Ambient temperature

12: CHCl₃

With Lawessons reagent; pyridine; sodium hydroxide; dipyridinium dichromate; oxalyl dichloride; sulfur; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762

Reference yield:

: 130312-22-0
3-butyne phenyl carbonate

: 141733-86-0
3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

Guidance literature:: Multi-step reaction with 12 steps

1: 0.5 h / 110 °C

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, from -70 deg C to -50 deg C, 30 min, 2.) CH₂Cl₂, from -50 deg C to RT

3: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

4: 247 g / CHCl₃ / Ambient temperature

5: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

6: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

7: Et₃N / toluene / Heating

8: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 1.5 h / 80 °C

9: 37 percent / dioxane / 2 h / 130 °C

10: 58 percent / TFA / CHCl₃ / 0 °C

11: pyridinium dichromate (PDC) / dimethylformamide / 15 h / Ambient temperature

12: CHCl₃

With Lawessons reagent; pyridine; sodium hydroxide; dipyridinium dichromate; oxalyl dichloride; sulfur; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762

Reference yield:

: 141733-73-5
2-chloro-4-(3-hydroxypropyl)benzonitrile

: 141733-86-0
3-(3-butynyloxycarbonyl)-6-<2-chloro-4-<3-(diphenylmethoxycarbonyl)propyl>phenyl>-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>-triazolo<4,3-a><1,4,>diazepine

Guidance literature:: Multi-step reaction with 13 steps

1: 73 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

2: 1.) LDA / 1.) THF, -70deg C, 30 min, 2.) THF, -70 deg C, 30 min

3: conc. HCl / methanol / 0.25 h / 50 °C

4: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

5: 247 g / CHCl₃ / Ambient temperature

6: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

7: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

8: Et₃N / toluene / Heating

9: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 1.5 h / 80 °C

10: 37 percent / dioxane / 2 h / 130 °C

11: 58 percent / TFA / CHCl₃ / 0 °C

12: pyridinium dichromate (PDC) / dimethylformamide / 15 h / Ambient temperature

13: CHCl₃

With Lawessons reagent; pyridine; hydrogenchloride; sodium hydroxide; dipyridinium dichromate; sulfur; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762