2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine

Base Information

• Chemical Name: 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine
• CAS No.: 29528-16-3
• Molecular Formula: C₁₄H₁₃N₃O
• Molecular Weight: 239.277
• Mol file: 29528-16-3.mol

Synonyms:

Chemical Property of 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine

There total 2 articles about 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-2-nitroaniline (16133-49-6) → 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine (29528-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂ / methanol / 2 h / 20 °C / 1551.49 Torr

2.1: oxone (R) / dimethylformamide / 2 h / 20 °C

2.2: 93 percent / H₂ / Pd/C / methanol / 2 h / 20 °C / 1551.49 Torr

With Oxone; hydrogen; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397910701489453

Reference yield:

→ 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine (29528-16-3)

Guidance literature:

/BRN= 581416/, Zinn, h. konz. HCl, Red.;

Reference yield:

Benzyl isothiocyanate (622-78-6) + 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine (29528-16-3) → benzyl-(9-methoxy-benzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-amine + benzyl-(10-methoxy-benzo[4,5]imidazo[1,2-c]qinazolin-6-yl)-amine

Guidance literature:

Benzyl isothiocyanate; 2-(6-methoxy-1H-benzimidazol-2-yl)-phenylamine; In dimethyl sulfoxide; at 20 ℃; for 2h;

With triethylamine; mercury dichloride; In dimethyl sulfoxide; Further stages. Title compound not separated from byproducts.;

DOI:10.1080/00397910701489453

upstream raw materials:

5-methoxy-2-nitroaniline

Refernces