7α-(p-bromophenyl)hydrocodone

Base Information

• Chemical Name: 7α-(p-bromophenyl)hydrocodone
• CAS No.: 212553-44-1
• Molecular Formula: C₂₄H₂₄BrNO₃
• Molecular Weight: 454.363
• Mol file: 212553-44-1.mol

Synonyms:

Chemical Property of 7α-(p-bromophenyl)hydrocodone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7α-(p-bromophenyl)hydrocodone

There total 1 articles about 7α-(p-bromophenyl)hydrocodone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis-(4-bromo-phenyl)-iodonium ; iodide + Hydrocodone (125-29-1) → 7α-(p-bromophenyl)hydrocodone (212553-44-1)

Guidance literature:

With lithium hexamethyldisilazane; Yield given. Multistep reaction; 1.) hexane, -78 deg C, 30 min, 2.) hexane, DMF, -78 deg C, 2 h;

DOI:10.1021/jm9802214

Reference yield:

7α-(p-bromophenyl)hydrocodone (212553-44-1) → 17-methyl-3-methoxy-4,5α-epoxy-7α-(p-bromophenyl)morphinan-6α-ol (212553-47-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 22h; Ambient temperature;

DOI:10.1021/jm9802214

Reference yield:

7α-(p-bromophenyl)hydrocodone (212553-44-1) → 17-methyl-4,5α-epoxy-7α-(p-bromophenyl)morphinan-3,6α-diol

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 22 h / Ambient temperature

2: 34 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

With sodium tetrahydroborate; boron tribromide; In ethanol; dichloromethane;

DOI:10.1021/jm9802214

upstream raw materials:

Hydrocodone

Downstream raw materials:

17-methyl-3-methoxy-4,5α-epoxy-7α-(p-bromophenyl)morphinan-6α-ol