1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide

Base Information

Chemical Name:1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide
CAS No.:85815-34-5
Molecular Formula:C₂₈H₂₀Cl₂N₆O₅
Molecular Weight:591.41
Hs Code.:

1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide

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Chemical Property of 1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide

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Technology Process of 1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide

There total 2 articles about 1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65698-98-8
C₁₇H₁₅Cl₂N₃O₃

: 85815-34-5
1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / methanol / 96 h / Ambient temperature

2: 1) THF, hexamethylphosphoramide, r.t., 4 h, 2) acetic acid, reflux, 1.5 h

In methanol;
DOI:10.1002/jhet.5570190621

Reference yield:

: 59180-28-8
phthalylglycylglycyl chloride

: 85815-31-2
C₁₆H₁₄Cl₂N₄O₂

: 85815-34-5
1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid methylamide

Guidance literature:: Yield given. Multistep reaction; 1) THF, hexamethylphosphoramide, r.t., 4 h, 2) acetic acid, reflux, 1.5 h;
DOI:10.1002/jhet.5570190621