Technology Process of Quinoline, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-, dihydrochloride
There total 8 articles about Quinoline, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-, dihydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: PCl5 / 0.5 h / 50 °C
2: AlCl3 / 1 h
3: 86 percent / H2 / 5percent Pd/C / ethanol
4: 92 percent / NaOAc
5: 84 percent / NaOCH3 / ethanol / 1 h / Heating
6: 86 percent / SOCl2/DMF / CHCl3 / 0.5 h / 50 °C
7: 80 percent / 2 h / 130 °C
8: 83 percent / NaCO3 / butan-2-one / 20 h / Heating
With
aluminium trichloride; thionyl chloride; phosphorus pentachloride; hydrogen; sodium methylate; sodium acetate; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
ethanol; chloroform; butanone;
DOI:10.1248/cpb.37.110
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 86 percent / H2 / 5percent Pd/C / ethanol
2: 92 percent / NaOAc
3: 84 percent / NaOCH3 / ethanol / 1 h / Heating
4: 86 percent / SOCl2/DMF / CHCl3 / 0.5 h / 50 °C
5: 80 percent / 2 h / 130 °C
6: 83 percent / NaCO3 / butan-2-one / 20 h / Heating
With
thionyl chloride; hydrogen; sodium methylate; sodium acetate; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
ethanol; chloroform; butanone;
DOI:10.1248/cpb.37.110