Levonorgestrel IMpurity N

Base Information

• Chemical Name: Levonorgestrel IMpurity N
• CAS No.: 4222-96-2
• Molecular Formula: C₁₉H₂₆O₂
• Molecular Weight: 286.414
• Mol file: 4222-96-2.mol

Synonyms:

Chemical Property of Levonorgestrel IMpurity N

Chemical Property:

• Melting Point: 131-134°C
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 13-Ethylgon-5(10)en-3,17-dione is an impurity from the synthesis of Levonorgestrel (N689510), an oral contraceptive. 13-Ethylgon-5(10)en-3,17-dione (Levonorgestrel EP Impurity N) is an impurity from the synthesis of Levonorgestrel (N689510), an oral contraceptive.

Technology Process of Levonorgestrel IMpurity N

There total 6 articles about Levonorgestrel IMpurity N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one (2322-77-2) → DL-13β-ethyl-gon-5(10)-ene-3,17-dione (4222-96-2)

Guidance literature:

With oxalic acid; silica gel; In methanol; dichloromethane; water; for 0.25h; Ambient temperature;

Reference yield:

18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol (7443-72-3) → DL-13β-ethyl-gon-5(10)-ene-3,17-dione (4222-96-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NH₃ liq., Li / propan-2-ol; tetrahydrofuran / -45 °C

2: 85 percent / Py*SO₃ / dimethylsulfoxide; triethylamine / Ambient temperature

3: 92 percent / oxalic acid, silica gel / CH₂Cl₂; methanol; H₂O / 0.25 h / Ambient temperature

With ammonia; sulfur trioxide pyridine complex; oxalic acid; silica gel; lithium; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; triethylamine; isopropyl alcohol;

Reference yield:

D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene (14507-49-4) → DL-13β-ethyl-gon-5(10)-ene-3,17-dione (4222-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Py*SO₃ / dimethylsulfoxide; triethylamine / Ambient temperature

2: 92 percent / oxalic acid, silica gel / CH₂Cl₂; methanol; H₂O / 0.25 h / Ambient temperature

With sulfur trioxide pyridine complex; oxalic acid; silica gel; In methanol; dichloromethane; water; dimethyl sulfoxide; triethylamine;

upstream raw materials:

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol

D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene

Downstream raw materials:

DL-13β-ethyl-11β-hydroxy-gon-4-en-3,17-dione

DL-13β-ethyl-gona-4,9-diene-3,17-dione