26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane

Base Information

• Chemical Name: 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane
• CAS No.: 177089-52-0
• Molecular Formula: C₂₆H₄₆N₄O₄
• Molecular Weight: 478.676
• Mol file: 177089-52-0.mol

Synonyms:

Chemical Property of 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane

There total 8 articles about 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-tolylsulphonyl)-3,9-dioxa-6-azaundecane-1,11-diamine (132930-17-7) → 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane (177089-52-0)

Guidance literature:

Multi-step reaction with 6 steps

1: benzene / 4 h / Heating

2: H₂ / PtO₂ / acetic acid / 6 h / Ambient temperature

3: 45 percent / Na₂CO₃ / acetonitrile / 96 h / Heating

4: 87 percent / H₂ / Pd/C / acetic acid / Ambient temperature

5: 0.48 g / Na₂CO₃ / acetonitrile / 144 h / Heating

6: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; acetic acid; acetonitrile; benzene;

DOI:10.1021/jo952283x

Reference yield:

1,11-diphthalimido-6-(4-tolylsulphonyl)-3,9-dioxa-6-azaundecane (132930-16-6) → 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane (177089-52-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 98 percent / hydrazine hydrate / ethanol / 5 h / Heating

2: benzene / 4 h / Heating

3: H₂ / PtO₂ / acetic acid / 6 h / Ambient temperature

4: 45 percent / Na₂CO₃ / acetonitrile / 96 h / Heating

5: 87 percent / H₂ / Pd/C / acetic acid / Ambient temperature

6: 0.48 g / Na₂CO₃ / acetonitrile / 144 h / Heating

7: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; hydrazine hydrate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; acetonitrile; benzene;

DOI:10.1021/jo952283x

Reference yield:

6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate) (80639-61-8) → 26-benzyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane (177089-52-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 80 percent / dimethylformamide / 48 h / 110 °C

2: 98 percent / hydrazine hydrate / ethanol / 5 h / Heating

3: benzene / 4 h / Heating

4: H₂ / PtO₂ / acetic acid / 6 h / Ambient temperature

5: 45 percent / Na₂CO₃ / acetonitrile / 96 h / Heating

6: 87 percent / H₂ / Pd/C / acetic acid / Ambient temperature

7: 0.48 g / Na₂CO₃ / acetonitrile / 144 h / Heating

8: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; hydrazine hydrate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jo952283x

upstream raw materials:

26-benzyl-7,19-di-p-toluenesulfonyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazabicyclo[12.12.3]heptacosane

6-(4-tolylsulphonyl)-3,9-dioxa-6-azaundecane-1,11-diamine

1,11-diphthalimido-6-(4-tolylsulphonyl)-3,9-dioxa-6-azaundecane

6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate)