C₃₀H₂₈O₁₀

Base Information

• Chemical Name: C₃₀H₂₈O₁₀
• CAS No.: 439857-46-2
• Molecular Formula: C₃₀H₂₈O₁₀
• Molecular Weight: 548.546
• Mol file: 439857-46-2.mol

Synonyms:

Chemical Property of C₃₀H₂₈O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₂₈O₁₀

There total 24 articles about C₃₀H₂₈O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H29ClO11 → C30H28O10 (439857-46-2)

Guidance literature:

With propylamine; In tetrahydrofuran; at 0 ℃; Yield given;

DOI:10.1021/ja9618863

Reference yield:

2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid (137434-21-0) + C19H19ClO8 (183733-32-6) → C30H28O10 (439857-46-2)

Guidance literature:

2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid; C₁₉H₁₉ClO₈; In tetrahydrofuran; at -10 ℃; for 0.25h;

With dicyclohexyl-carbodiimide; at -10 ℃; for 0.166667h;

With propylamine; at -10 ℃; for 0.166667h; Further stages.;

DOI:10.1021/ja012487x

Reference yield:

(R)-1-{(2R,3R)-3-[(tert-Butyl-dimethyl-silanyl)-ethynyl]-2-ethynyl-oxiranyl}-ethane-1,2-diol (183733-37-1) → C30H28O10 (439857-46-2)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 91 percent / p-toluenesulfonic acid / dimethylformamide / 6 h / 23 °C

2.1: lithium hexamethyldisilazide / toluene / 0.42 h / -78 °C

2.2: 5.55 g / toluene / 0.67 h / -78 °C

3.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4.1: 92 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 0 - 23 °C

5.1: 90 percent / p-toluenesulfonic acid / acetone / 0.25 h / 23 °C

6.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / -78 °C

7.1: 94 percent / diisobutylaluminum hydride / toluene; CH₂Cl₂ / 0.17 h / -78 °C

8.1: (+)-diethyl-L-tartrate; titanium(IV) isopropoxide / CH₂Cl₂ / 0.5 h

8.2: 98 percent / tert-butyl hydroperoxide / CH₂Cl₂ / 15 h

9.1: 97 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.67 h / 23 °C

10.1: 85 percent / 1,3-diphenyl-1,1,3,3-tetramethyldisilazine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

11.1: 89 percent / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

12.1: 100 percent / Et₃N*3HF / tetrahydrofuran / 2.5 h / 23 °C

13.1: tetrahydrofuran / 0.25 h / -10 °C

13.2: DCC / 0.17 h / -10 °C

13.3: n-propylamine / 0.17 h / -10 °C

With pyridine; 2,6-dimethylpyridine; titanium(IV) isopropylate; dmap; n-butyllithium; diethyl L-tartrate; 1,1,3,3-tetramethyl-1,3-diphenyldisilazane; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine tris(hydrogen fluoride); triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1021/ja012487x

upstream raw materials:

2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid

C₁₉H₁₉ClO₈

2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid methyl ester

(R)-1-{(2R,3R)-3-[(tert-Butyl-dimethyl-silanyl)-ethynyl]-2-ethynyl-oxiranyl}-ethane-1,2-diol

Downstream raw materials:

C₂₇H₂₄O₁₀

neocarzinostatin chromophore

C₂₈H₂₀O₁₀

C₂₈H₂₂O₁₁