4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3-pentadienyl]-2-(2,4 ,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3-pentadienyl]-2-(2,4 ,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester
CAS No.:105228-56-6
Molecular Formula:C32H32N2O7
Molecular Weight:556.615
Hs Code.:
Mol file:105228-56-6.mol

4-Oxazolecarboxylic acid,
2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3-pentadienyl]-2-(2,4
,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3-pentadienyl]-2-(2,4 ,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3-pentadienyl]-2-(2,4 ,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

There total 4 articles about 4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3-pentadienyl]-2-(2,4 ,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.6%

: 136918-14-4,85-41-6
phthalimide

: 1883-19-8
vinyltri-n-butylphosphonium bromide

: 105307-17-3
2-[(4R,6S)-6-((E)-3-Oxo-propenyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

: 105228-56-6
2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 23 ℃; for 46h;
DOI:10.1021/jo00376a011

Reference yield:

: 105228-54-4
2-[(4R,6S)-6-Formyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

: 105228-56-6
2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / benzene / 24 h / Heating

2: 26.6 percent / NaH / tetrahydrofuran / 46 h / 23 °C

With sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1021/jo00376a011

Reference yield:

: 105228-53-3
2-[(4R,6S)-6-Hydroxymethyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

: 105228-56-6
2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH₂Cl₂, 20 min, -55 deg C, 2.) from -70 deg C to 35 deg C

2: 77 percent / benzene / 24 h / Heating

3: 26.6 percent / NaH / tetrahydrofuran / 46 h / 23 °C

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1021/jo00376a011