2-Amino-3-phenyl-4,4,4-trifluorobutyric acid

Base Information

• Chemical Name: 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid
• CAS No.: 114829-12-8
• Molecular Formula: C₁₀H₁₀F₃NO₂
• Molecular Weight: 233.19

Synonyms:

Chemical Property of 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

β-(Trifluoromethyl)phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: β-(Trifluoromethyl)phenylalanine is a protected amino acid used in the synthesis of pharmacologically active compounds. Phenylalanine (P319415) is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine.

Technology Process of 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid

There total 2 articles about 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-Phenyl-4-(1-phenyl-2,2,2-trifluoroethylidine)oxazol-5-one (114829-08-2) → 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid (114829-12-8)

Guidance literature:

With phosphorus; hydrogen iodide; In acetic anhydride; for 4h; Heating;

DOI:10.1007/BF00758437

Reference yield:

2,2,2-Trifluoroacetophenone (434-45-7) → 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid (114829-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium carbonate, Ac₂O / 2.) 50 deg C; r.t., overnight

2: 41 percent / red phosphorus, 50 percent aq. HI / acetic anhydride / 4 h / Heating

With phosphorus; hydrogen iodide; acetic anhydride; potassium carbonate; In acetic anhydride;

DOI:10.1007/BF00758437

upstream raw materials:

2-Phenyl-4-(1-phenyl-2,2,2-trifluoroethylidine)oxazol-5-one

2,2,2-Trifluoroacetophenone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 114829-12-8 2-Amino-3-phenyl-4,4,4-trifluorobutyric acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send