Technology Process of 2-(6-Bromo-3,4-dimethoxy-2-methyl-phenyl)-2-((S)-2-phenyl-propyl)-[1,3]dioxolane
There total 14 articles about 2-(6-Bromo-3,4-dimethoxy-2-methyl-phenyl)-2-((S)-2-phenyl-propyl)-[1,3]dioxolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at -78 ℃;
for 4h;
Yield given;
DOI:10.1016/0040-4039(95)01981-M
- Guidance literature:
-
Multi-step reaction with 10 steps
1: BCl3*SMe2 / 1,2-dichloro-ethane / 83 °C
2: NaOH / H2O / 100 °C
3: LiAlH4 / diethyl ether / Ambient temperature
4: DMAP, pyridine / CH2Cl2 / Ambient temperature
5: Br2 / acetic acid / Ambient temperature
6: K2CO3 / methanol; tetrahydrofuran / Ambient temperature
7: Dess-Martin periodinane / CH2Cl2 / Ambient temperature
8: 78 percent / 1.) Mg / tetrahydrofuran / 1.) RT down to 0 deg C, 0.5 h; 2.) 0 deg C
9: (COCl)2/DMSO, Et3N / CH2Cl2 / 1 h / -78 deg C up to RT
10: TMSOTf / CH2Cl2 / 4 h / -78 °C
With
pyridine; dmap; sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; boron trichloride - methyl sulfide complex; bromine; potassium carbonate; Dess-Martin periodane; magnesium; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(95)01981-M
- Guidance literature:
-
Multi-step reaction with 6 steps
1: LiAlH4 / tetrahydrofuran / 12 h / 65 °C
2: 1.) Na/NH3; 2.) t-BuOK / 1.) EtOH, -78 deg C, 6 h; 2.) DMSO, 65 deg C down to RT, 2 h
3: 86 percent / PPh3, NBS, pyridine / CH2Cl2 / 1 h / Ambient temperature
4: 78 percent / 1.) Mg / tetrahydrofuran / 1.) RT down to 0 deg C, 0.5 h; 2.) 0 deg C
5: (COCl)2/DMSO, Et3N / CH2Cl2 / 1 h / -78 deg C up to RT
6: TMSOTf / CH2Cl2 / 4 h / -78 °C
With
pyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; ammonia; sodium; magnesium; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4039(95)01981-M
