4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Base Information

Chemical Name:4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester
CAS No.:137302-18-2
Molecular Formula:C₃₅H₄₃ClF₃N₅O₉S
Molecular Weight:802.269
Hs Code.:

4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Synonyms:

Suppliers and Price of 4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

There total 13 articles about 4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 137302-18-2,137302-19-3
4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: CDI / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 N aq. KOH / ethanol / 16 h / Ambient temperature

3: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

4: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

6: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With potassium hydroxide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: 4-(Ethoxycarbonylmethyl-amino)-piperidine-1-carboxylic acid ethyl ester

: 137302-18-2,137302-19-3
4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: CDI / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 N aq. KOH / ethanol / 16 h / Ambient temperature

3: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

4: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

6: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With potassium hydroxide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: 4-[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-carboxymethyl-amino]-piperidine-1-carboxylic acid ethyl ester

: 137302-18-2,137302-19-3
4-{{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-amino}-piperidine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

2: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

3: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

4: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005