2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

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Chemical Name:2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate
CAS No.:72866-83-2
Molecular Formula:C₂₃H₁₇NO₅
Molecular Weight:387.392
Hs Code.:

2,3-Dihydro-11-(hydroxymethyl)-1H-benzo<f>pyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

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Chemical Property of 2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

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Technology Process of 2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

There total 7 articles about 2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72866-69-4
2-Allyl-1,4-dimethoxy-3-<2-(methoxycarbonyl)-1-pyrrolidinyl>naphthalene

: 72866-83-2
2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

Guidance literature:: Multi-step reaction with 8 steps

1: 72.1 percent / LiIO₄ in situ / OsO₄ / ethyl acetate; various solvent(s); H₂O / 24 h

2: 74 percent / p-TsOH*H₂O / methanol / 4 h / Ambient temperature

3: aq. KOH / 0.5 h / Heating

4: 1) POCl₃, 2) MeOH

5: 64 percent / DDQ / CH₂Cl₂; acetone / 1 h

6: 96 percent / (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 0.75 h

7: 59.3 percent / 1) NaBH₄, 2) FeCl₃/aq. HCl / 1) MeOH, 40 min, reflux, 2) acetone, 15 min

8: 96.1 percent / pyridine; CH₂Cl₂ / Ambient temperature

With hydrogenchloride; methanol; potassium hydroxide; sodium tetrahydroborate; ammonium cerium(IV) nitrate; lithium metaperiodate; iron(III) chloride; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; osmium(VIII) oxide; In pyridine; methanol; dichloromethane; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jo01295a020

Reference yield:

: 72881-47-1
2,3-Dihydro-1H-benzopyrrolo<1,2-a>indole-5,10-dione-11-carboxaldehyde

: 72866-83-2
2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 59.3 percent / 1) NaBH₄, 2) FeCl₃/aq. HCl / 1) MeOH, 40 min, reflux, 2) acetone, 15 min

2: 96.1 percent / pyridine; CH₂Cl₂ / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; iron(III) chloride; In pyridine; dichloromethane;
DOI:10.1021/jo01295a020

Reference yield:

: 72866-82-1
5,10-Dimethoxy-1,2-dihydro-3H-benzopyrrolo<1,2-a>-indole-11-carboxaldehyde

: 72866-83-2
2,3-Dihydro-11-(hydroxymethyl)-1H-benzopyrrolo<1,2-a>indole-5,10-dione Phenyl Carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 0.75 h

2: 59.3 percent / 1) NaBH₄, 2) FeCl₃/aq. HCl / 1) MeOH, 40 min, reflux, 2) acetone, 15 min

3: 96.1 percent / pyridine; CH₂Cl₂ / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; ammonium cerium(IV) nitrate; iron(III) chloride; In pyridine; dichloromethane; water; acetonitrile;
DOI:10.1021/jo01295a020