5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine

Base Information

• Chemical Name: 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine
• CAS No.: 127277-91-2
• Molecular Formula: C₄₄H₄₁N₅O₉S₂
• Molecular Weight: 847.97
• Mol file: 127277-91-2.mol

Synonyms:

Chemical Property of 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine

There total 4 articles about 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

2',3'-di-O-p-tolylsulphonyladenosine (40601-49-8) + mono-4-methoxytrityl chloride (14470-28-1) → 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine (127277-91-2) + C64H57N5O10S2

Guidance literature:

Ambient temperature;

DOI:10.1016/S0040-4020(01)89533-8

Reference yield:

N6-benzoyl-2',3'-di-O-p-tolylsulphonyladenosine (127246-75-7) → 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine (127277-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 150 mg / ammonia / methanol / Ambient temperature

2: 43 percent / Ambient temperature

With ammonia; In methanol;

DOI:10.1016/S0040-4020(01)89533-8

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 5'-O-monomethoxytrityl-2',3'-di-O-p-tolylsulphonyladenosine (127277-91-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 3 percent / pyridine / Ambient temperature

2: 150 mg / ammonia / methanol / Ambient temperature

3: 43 percent / Ambient temperature

With ammonia; In pyridine; methanol;

DOI:10.1016/S0040-4020(01)89533-8

upstream raw materials:

2',3'-di-O-p-tolylsulphonyladenosine

mono-4-methoxytrityl chloride

N⁶-benzoyl-2',3'-di-O-p-tolylsulphonyladenosine

p-toluenesulfonyl chloride

Downstream raw materials:

9-<5-O-(monomethoxytrityl)-3-deoxy-β-D-threo-pentofuranosyl>adenine

5'-O-(p-methoxyphenyldiphenylmethyl)adenosine