Technology Process of Ethyl cis-4-<2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)cyclopropyl>benzoate
There total 7 articles about Ethyl cis-4-<2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)cyclopropyl>benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 93 percent / NH2NH2*H2O / ethanol / 2.5 h / 0 to 20 deg C
2: 1) HgO, KOH / 1) Et2O, EtOH, 0 deg C, 15 min, then 25 dec C, 1 h, 2) hexane, then removing of the solvents, 80-100 deg C, 20 min
With
potassium hydroxide; hydrazine hydrate; mercury(II) oxide;
In
ethanol;
DOI:10.1021/jm00127a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 59 percent / AlCl3 / 0.33 h / 5 - 10 °C
2: 1) Mg, CH3I / 1) THF, 50-55 deg C, 30 min, 2) THF, -20 deg C to 0 deg C, 1 h
3: 1) n-BuLi / 1) THF, hexane, -30 to -5 deg C, 30 min, then -5 deg C, 30 min, 2) THF, -40 to 0 deg C, 1 h
4: 1) HgO, KOH / 1) Et2O, EtOH, 0 deg C, 15 min, then 25 dec C, 1 h, 2) hexane, then removing of the solvents, 80-100 deg C, 20 min
With
potassium hydroxide; n-butyllithium; aluminium trichloride; magnesium; mercury(II) oxide; methyl iodide;
DOI:10.1021/jm00127a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 59 percent / AlCl3 / 0.33 h / 5 - 10 °C
2: 1) Mg, CH3I / 1) THF, 50-55 deg C, 30 min, 2) THF, -20 deg C to 0 deg C, 1 h
3: 1) n-BuLi / 1) THF, hexane, -30 to -5 deg C, 30 min, then -5 deg C, 30 min, 2) THF, -40 to 0 deg C, 1 h
4: 1) HgO, KOH / 1) Et2O, EtOH, 0 deg C, 15 min, then 25 dec C, 1 h, 2) hexane, then removing of the solvents, 80-100 deg C, 20 min
With
potassium hydroxide; n-butyllithium; aluminium trichloride; magnesium; mercury(II) oxide; methyl iodide;
DOI:10.1021/jm00127a018
