3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

Base Information

Chemical Name:3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione
CAS No.:160234-43-5
Molecular Formula:C₃₁H₄₁F₃N₂O₁₀S₂Si₂
Molecular Weight:778.972
Hs Code.:

3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

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Chemical Property of 3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

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Technology Process of 3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

There total 5 articles about 3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 421-83-0
trifluoromethane sulfonyl chloride

: 160234-42-4
3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

: 160234-43-5
3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

Guidance literature:: With dmap; triethylamine; In pyridine; for 44h; Ambient temperature;
DOI:10.1080/15257779408011866

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 160234-43-5
3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) HMDS, ammonium sulfate, 2.) SnCl₄ / 1.) reflux, 5 h, 2.) 1,2-dichloroethane, RT, 18 h

2: 67 percent / ammonia / methanol / 72 h / Ambient temperature

3: 92 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

4: 32 percent / tetrabutylammonium bromide, aq. K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

5: 6 percent / triethylamine, DMAP / pyridine / 44 h / Ambient temperature

With 1H-imidazole; dmap; ammonium sulfate; tetrabutylammomium bromide; ammonia; tin(IV) chloride; potassium carbonate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408011866

Reference yield:

: 153085-39-3
1-(β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

: 160234-43-5
3-N-benzoyl-1-(3,5-O-tetraisopropyldisiloxan-1,3-diyl-2-O-trifluoromethanesulfonyl-β-D-ribofuranosyl)thieno<3,2-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 32 percent / tetrabutylammonium bromide, aq. K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

3: 6 percent / triethylamine, DMAP / pyridine / 44 h / Ambient temperature

With 1H-imidazole; dmap; tetrabutylammomium bromide; potassium carbonate; triethylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408011866