Technology Process of methyl-(5S)-(2-methoxy-4-methylphenyl)hexanoate
There total 11 articles about methyl-(5S)-(2-methoxy-4-methylphenyl)hexanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4S)-(2-methoxy-4-methylphenyl)hexanenitrile;
With
sodium hydroxide;
In
ethanol;
for 12h;
Heating;
diazomethane;
In
diethyl ether;
DOI:10.1248/cpb.49.1581
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: immobilized lipase (MY-30); H2O / diisopropyl ether / 72 h / 33 °C
2.1: H2 / 20 percent Pd(OH)2-C / ethyl acetate / 20 °C
3.1: pyridine / 12 h / 20 °C
4.1: 40 percent / NaBH4 / dimethylsulfoxide / 2 h / 80 °C
5.1: 48 percent / Ph3P; I2; imidazole / diethyl ether; acetonitrile / 0.5 h / 20 °C
6.1: 99 percent / dimethylformamide / 12 h / 20 °C
7.1: 2 M aq. NaOH / ethanol / 12 h / Heating
7.2: 54 percent / diethyl ether
With
pyridine; 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; immobilized lipase (MY-30); water; hydrogen; iodine; triphenylphosphine;
palladium hydroxide - carbon;
In
diethyl ether; ethanol; di-isopropyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1581
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: H2 / 20 percent Pd(OH)2-C / ethyl acetate / 20 °C
2.1: pyridine / 12 h / 20 °C
3.1: 40 percent / NaBH4 / dimethylsulfoxide / 2 h / 80 °C
4.1: 48 percent / Ph3P; I2; imidazole / diethyl ether; acetonitrile / 0.5 h / 20 °C
5.1: 99 percent / dimethylformamide / 12 h / 20 °C
6.1: 2 M aq. NaOH / ethanol / 12 h / Heating
6.2: 54 percent / diethyl ether
With
pyridine; 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; hydrogen; iodine; triphenylphosphine;
palladium hydroxide - carbon;
In
diethyl ether; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1581
