(1R,3S-)Solifenacin Hydrochloride

Base Information

Chemical Name:(1R,3S-)Solifenacin Hydrochloride
CAS No.:180468-40-0
Molecular Formula:C₂₃H₂₆N₂O₂*(x)ClH
Molecular Weight:398.92568
Hs Code.:
Mol file:180468-40-0.mol

Synonyms:

Suppliers and Price of (1R,3S-)Solifenacin Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1R,3S)-SolifenacinHydrochloride
2.5mg
$ 180.00

Medical Isotopes, Inc.
(1R,3S)-SolifenacinHCl
5 mg
$ 675.00

Total 7 raw suppliers

Chemical Property of (1R,3S-)Solifenacin Hydrochloride

Chemical Property:

Melting Point:>124°C (dec.)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(1R,3S)-SolifenacinHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (1R,3S-)Solifenacin Hydrochloride is an optical isomer of Solifenacin Hydrochloride (S676700), a muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence.

Technology Process of (1R,3S-)Solifenacin Hydrochloride

There total 7 articles about (1R,3S-)Solifenacin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 242478-37-1,180272-14-4
solifenacin

: 180468-37-5,180468-40-0
Solifenacin hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; butanone; at 20 ℃; Purification / work up;

Reference yield:

: 242478-37-1,180272-14-4
solifenacin

: 180468-37-5,180468-40-0
(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In ipa; ethanol; at 5 - 30 ℃;

Reference yield:

: 22990-19-8,96719-89-0,118864-75-8
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 25333-42-0
(R)-quinuclidin-3-ol

: 180468-37-5,180468-40-0
Solifenacin hydrochloride

Guidance literature:: (R)-quinuclidin-3-ol; With bis-(p-nitrophenyl) carbonate; In N,N-dimethyl-formamide; at 25 - 30 ℃;

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 3h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 25 - 30 ℃; pH=1 - 2;
DOI:10.1007/s00706-011-0610-7