(R)-α-(o-chlorophenyl)ethylamine

Base Information

• Chemical Name: (R)-α-(o-chlorophenyl)ethylamine
• CAS No.: 127852-23-7
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.627
• Mol file: 127852-23-7.mol

Synonyms:

Chemical Property of (R)-α-(o-chlorophenyl)ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-α-(o-chlorophenyl)ethylamine

There total 17 articles about (R)-α-(o-chlorophenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(2-chlorophenyl)ethanone (2142-68-9) → (R)-α-(o-chlorophenyl)ethylamine (39959-67-6,68285-26-7,127852-23-7,127733-42-0)

Guidance literature:

With pyridoxal 5'-phosphate; transaminase ATA-025; isopropylamine; In aq. phosphate buffer; acetonitrile; at 30 ℃; for 24h; pH=7.5; Solvent; stereoselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc01981a

Reference yield: 88.0%

2'-chloro-sec-phenethyl alcohol (13524-04-4) → 1-(2-Chloro-phenyl)-ethylamine (39959-67-6,68285-26-7,127733-42-0,127852-23-7)

Guidance literature:

With ammonium hydroxide; C₁₅H₂₉IrN₄⁽²⁺⁾*2I^(1-); at 150 ℃; for 40h; Sealed tube;

DOI:10.1002/cctc.201702037

Reference yield: 86.0%

N-((R)-1-(2-chlorophenyl)ethyl)-2-methylpropane-2-sulfinamide → (R)-α-(o-chlorophenyl)ethylamine (39959-67-6,68285-26-7,127852-23-7,127733-42-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

1-(2-chlorophenyl)ethanone

N-[1-(2-chloro-phenyl)-ethyl]-formamide

2'-chloro-sec-phenethyl alcohol

1-(2-Chloro-phenyl)-ethylamine

Downstream raw materials:

(S)-α-(o-chlorophenyl)ethylamine

(R)-α-(o-chlorophenyl)ethylamine

1-(2,6-dichlorophenyl)ethan-1-amine

C₂₁H₁₉ClN₄O

Refernces

• 1、 Dai, Zengjin,Pan, Ying-Min,Wang, Shou-Guo,Yin, Qin,Zhang, Xumu. "Direct reductive amination of ketones with ammonium salt catalysed by Cp*Ir(iii) complexes bearing an amidato ligand". supporting information. p. 8934 - 8939. Retrieved 2021/11/04.
• 2、 Tanaka, Kouichi,Miki, Takashi,Murata, Kunihiko,Yamaguchi, Ayumi,Kayaki, Yoshihito,Kuwata, Shigeki,Ikariya, Takao,Watanabe, Masahito. "Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand". . p. 10962 - 10977. Retrieved 2019/09/03.