[(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

Base Information

Chemical Name:[(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester
CAS No.:90362-83-7
Molecular Formula:C₃₁H₄₈F₃N₃O₈S
Molecular Weight:679.799
Hs Code.:

[(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

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Chemical Property of [(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

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Technology Process of [(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

There total 9 articles about [(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61341-03-5
N-(toluene-4-sulfonyl)-β-alanyl chloride

: 90362-83-7
[(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) H₂, 10percent Pd-C; 2.) K₂CO₃ / 1.) EtOH, r.t.; 2.) PhH-PhMe-H₂O, O deg C to r.t.

2: 1.) H₂, Pd-C, p-TsOH*H₂O / 1.) EtOH, r.t.; 2.) Py, 0 deg C to r.t.

3: 50 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 24 h / 115 °C

4: 87 percent / LiAlH₄ / tetrahydrofuran / Heating

5: 61 percent / K₂CO₃ / dimethylformamide / Ambient temperature

6: 83 percent / iso-Pr₂NEt / CH₂Cl₂ / 0 - 25 °C

7: 1.) 80percent NH₂NH₂; 2.) K₂CO₃ / 1.) EtOH, r.t.; 2.) CH₂Cl₂-MeCN -55 to -50 deg C

With palladium on activated charcoal; lithium aluminium tetrahydride; hydrogen; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 90362-78-0
N-{3-[(2R,6S)-2-(2,2-Diethoxy-ethyl)-6-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-4-methyl-benzenesulfonamide

: 90362-83-7
[(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / K₂CO₃ / dimethylformamide / Ambient temperature

2: 83 percent / iso-Pr₂NEt / CH₂Cl₂ / 0 - 25 °C

3: 1.) 80percent NH₂NH₂; 2.) K₂CO₃ / 1.) EtOH, r.t.; 2.) CH₂Cl₂-MeCN -55 to -50 deg C

With potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: Phenyl-acetic acid (2R,3S,6S)-3-benzyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridin-1-yl ester

: 90362-83-7
[(2R,6R)-6-[(R)-1-(2-Methoxy-ethoxymethoxy)-propyl]-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / Py / 80 - 85 °C

2: 1.) H₂, 10percent Pd-C; 2.) K₂CO₃ / 1.) EtOH, r.t.; 2.) PhH-PhMe-H₂O, O deg C to r.t.

3: 1.) H₂, Pd-C, p-TsOH*H₂O / 1.) EtOH, r.t.; 2.) Py, 0 deg C to r.t.

4: 50 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 24 h / 115 °C

5: 87 percent / LiAlH₄ / tetrahydrofuran / Heating

6: 61 percent / K₂CO₃ / dimethylformamide / Ambient temperature

7: 83 percent / iso-Pr₂NEt / CH₂Cl₂ / 0 - 25 °C

8: 1.) 80percent NH₂NH₂; 2.) K₂CO₃ / 1.) EtOH, r.t.; 2.) CH₂Cl₂-MeCN -55 to -50 deg C

With pyridine; palladium on activated charcoal; lithium aluminium tetrahydride; hydrogen; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;