Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis-

Base Information

Chemical Name:Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis-
CAS No.:105310-08-5
Molecular Formula:C₁₃H₁₈N₂O
Molecular Weight:218.299
Hs Code.:
DSSTox Substance ID:DTXSID701156055

Synonyms:DTXSID701156055;Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis-;105310-08-5

Suppliers and Price of Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis-

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:218.141913202
Heavy Atom Count:16
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C(=O)C1(CC1CN)C2=CC=CC=C2
Isomeric SMILES:CN(C)C(=O)[C@@]1(C[C@@H]1CN)C2=CC=CC=C2

Technology Process of Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis-

There total 4 articles about Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-dimethyl-1-phenyl-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105310-74-5
(1S,2R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid dimethylamide

: 105310-08-5
(1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid dimethylamide

Guidance literature:: With hydrazine; In ethanol; Heating;
DOI:10.1021/jm00385a013

Reference yield:

: 105310-66-5
(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid chloride

: 105310-08-5
(1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / Ambient temperature

2: dimethylformamide / 2.5 h / 110 °C

3: H₂NNH₂ / ethanol / Heating

With hydrazine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013

Reference yield:

: 69160-63-0
(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

: 105310-08-5
(1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / SOCl₂ / 2 h / Heating

2: diethyl ether / Ambient temperature

3: dimethylformamide / 2.5 h / 110 °C

4: H₂NNH₂ / ethanol / Heating

With thionyl chloride; hydrazine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013