Cyclopropanecarboxamide, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N-ethyl-N-(2-hydroxy ethyl)-1-phenyl-, cis-

Base Information

Chemical Name:Cyclopropanecarboxamide, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N-ethyl-N-(2-hydroxy ethyl)-1-phenyl-, cis-
CAS No.:105310-83-6
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:
Mol file:105310-83-6.mol

Synonyms:

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Chemical Property of Cyclopropanecarboxamide, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N-ethyl-N-(2-hydroxy ethyl)-1-phenyl-, cis-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Cyclopropanecarboxamide, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N-ethyl-N-(2-hydroxy ethyl)-1-phenyl-, cis-

There total 3 articles about Cyclopropanecarboxamide, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N-ethyl-N-(2-hydroxy ethyl)-1-phenyl-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63106-93-4
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

: 105310-83-6
(1R,2S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid ethyl-(2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / dimethylformamide / 15 h / Heating

2: SOCl₂ / 4 h / Heating

3: CH₂Cl₂ / 15 h / Ambient temperature

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013

Reference yield:

: 1074-82-4
potassium phtalimide

: 105310-83-6
(1R,2S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid ethyl-(2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / dimethylformamide / 15 h / Heating

2: SOCl₂ / 4 h / Heating

3: CH₂Cl₂ / 15 h / Ambient temperature

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013

Reference yield:

: 69160-56-1
(Z)-1-phenyl-2-(phthalimidomethyl)cyclopropanecarboxylic acid

: 105310-83-6
(1R,2S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid ethyl-(2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 4 h / Heating

2: CH₂Cl₂ / 15 h / Ambient temperature

With thionyl chloride; In dichloromethane;
DOI:10.1021/jm00385a013