N-glycine benzyl ester

Base Information

• Chemical Name: N-glycine benzyl ester
• CAS No.: 162377-51-7
• Molecular Formula: C₃₆H₃₈N₂O₅S₂
• Molecular Weight: 642.84
• Mol file: 162377-51-7.mol

Synonyms:

Chemical Property of N-glycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-glycine benzyl ester

There total 3 articles about N-glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

glycine benzyl ester p-toluenesulfonic acid salt (1738-76-7) + Boc-Cys(STrt)-ONSu → N-glycine benzyl ester (162377-51-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h; Ambient temperature;

DOI:10.1002/recl.19951140102

Reference yield:

S-(tritylsulfenyl)cysteine (156312-01-5) → N-glycine benzyl ester (162377-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent

3: 72 percent / i-Pr₂EtN / dimethylformamide / 0.17 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1002/recl.19951140102

Reference yield:

N-(tert-Butyloxycarbonyl)-S-(tritylsulfanyl)cysteine (162377-49-3) → N-glycine benzyl ester (162377-51-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 72 percent / i-Pr₂EtN / dimethylformamide / 0.17 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1002/recl.19951140102

upstream raw materials:

glycine benzyl ester p-toluenesulfonic acid salt

S-(tritylsulfenyl)cysteine

N-(tert-Butyloxycarbonyl)-S-(tritylsulfanyl)cysteine