Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

Base Information

Chemical Name:Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester
CAS No.:191528-79-7
Molecular Formula:C₃₂H₃₆N₂O₁₀P₂
Molecular Weight:670.593
Hs Code.:

Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

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Chemical Property of Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

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Technology Process of Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

There total 9 articles about Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053252-81-5
C₃₂H₃₆N₂O₉P₂

: 191528-79-7
Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 0.25h; Yield given;
DOI:10.1016/S0040-4020(97)00387-6

Reference yield:

: 2,3-O-(R)-benzylidene-D-ribono-1,4-lactone

: 191528-79-7
Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaOH, 2.) NaIO₄ / 1.) H₂O, 45 deg C, 30 min, 2.) 0 deg C, 45 min

2: 94 percent / PPTS / CH₂Cl₂ / 5 h

3: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 45 min

4: 55 percent / benzophenone / 1.5 h / Irradiation

5: 94 percent / hlacial AcOH, NaBH₄ / benzene / 48 h / Ambient temperature

6: 1.) i-Pr₂NEt, 2.) DMAP / 1.) CH₂Cl₂, 44 h, 2.) 68 h

7: 1H-tetrazole / tetrahydrofuran / 3 h

8: mCPBA / CH₂Cl₂ / 0.25 h / 0 - 20 °C

With 1H-tetrazole; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; n-butyllithium; benzophenone; pyridinium p-toluenesulfonate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/S0040-4020(97)00387-6

Reference yield:

: 191528-75-3
(2R,3R)-O-benzylidene-2,3-dihydroxycyclopent-4-enone

: 191528-79-7
Morpholin-4-yl-phosphonic acid 2-cyano-ethyl ester (2R,3aR,4S,6R,6aR)-6-(diphenoxy-phosphoryloxymethyl)-2-phenyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / benzophenone / 1.5 h / Irradiation

2: 94 percent / hlacial AcOH, NaBH₄ / benzene / 48 h / Ambient temperature

3: 1.) i-Pr₂NEt, 2.) DMAP / 1.) CH₂Cl₂, 44 h, 2.) 68 h

4: 1H-tetrazole / tetrahydrofuran / 3 h

5: mCPBA / CH₂Cl₂ / 0.25 h / 0 - 20 °C

With 1H-tetrazole; dmap; sodium tetrahydroborate; benzophenone; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/S0040-4020(97)00387-6