Technology Process of ((1bS,4aS,5S)-5-Benzyloxymethyl-1b,4a,5,5a-tetrahydro-1aH-1,4-dioxa-2-aza-cyclopropa[a]pentalen-3-yl)-dimethyl-amine
There total 15 articles about ((1bS,4aS,5S)-5-Benzyloxymethyl-1b,4a,5,5a-tetrahydro-1aH-1,4-dioxa-2-aza-cyclopropa[a]pentalen-3-yl)-dimethyl-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetyl peroxide;
In
trifluoroacetic acid;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.) Pd<(OiPr)3P>4, triisopropyl phosphite / 1.) THF, a) RT, 5 h, b) 70 deg C, 40 min, 2.) THF, 70 deg C, 24 h
2: 91.5 percent / sodium naphthalenide / 1,2-dimethoxy-ethane; tetrahydrofuran / -78 °C
3: CH2Cl2 / 35 h / Ambient temperature
4: CH2Cl2 / 1.) 0 deg C, 2 h, 2.) from 0 deg C to RT, 9 h
5: 1.) CF3CO3H, 2.) 50percent aq. CF3COOH / 1.) CF3COOH, from 0 deg C to RT, 1.5 h, 2.) 40 deg C, 4.5 h
With
{(i-C3H7O)3P}4Pd; triisopropyl phosphite; trifluoroacetyl peroxide; sodium naphthalenide; trifluoroacetic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja00055a013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: CH2Cl2 / 35 h / Ambient temperature
2: CH2Cl2 / 1.) 0 deg C, 2 h, 2.) from 0 deg C to RT, 9 h
3: 1.) CF3CO3H, 2.) 50percent aq. CF3COOH / 1.) CF3COOH, from 0 deg C to RT, 1.5 h, 2.) 40 deg C, 4.5 h
With
trifluoroacetyl peroxide; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/ja00055a013
