1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine

Base Information

Chemical Name:1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine
CAS No.:131132-14-4
Molecular Formula:C₂₆H₂₆N₂O₇
Molecular Weight:481.478
Hs Code.:

Synonyms:

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Chemical Property of 1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine

Chemical Property:

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Technology Process of 1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine

There total 8 articles about 1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 131132-14-4
1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

2: 83 percent / HCl, HOAc

3: CHCl₃ / 2 h

With hydrogenchloride; dmap; acetic acid; In pyridine; chloroform;
DOI:10.1021/jo00004a040

Reference yield:

: 131132-17-7
2,2'-dideuterio-2-deoxyribonolactone

: 131132-14-4
1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / pyridine / tetrahydrofuran / 8 h

2: 82 percent / diisobutylaluminium deuteride (Dibal-D) / hexane; diethyl ether; CH₂Cl₂ / 2 h / -78 °C

3: 1.) HCl, Ag₂CO₃, 2.) tetra-n-butylammonium fluoride / 1.) 15 min, room temp., 2.) 30 min, room temp., THF

4: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

5: 83 percent / HCl, HOAc

6: CHCl₃ / 2 h

With pyridine; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; diisobutylaluminium deuteride; acetic acid; silver carbonate; In tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane; chloroform;
DOI:10.1021/jo00004a040

Reference yield:

: 131132-08-6
2,2'-dideuterio-3,5-bis-O-(tert-butyldimethylsilyl)-2-deoxyribonolactone

: 131132-14-4
1',2',2''-trideuterio-3',5'-di-O-p-toluoylthymidine

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / diisobutylaluminium deuteride (Dibal-D) / hexane; diethyl ether; CH₂Cl₂ / 2 h / -78 °C

2: 1.) HCl, Ag₂CO₃, 2.) tetra-n-butylammonium fluoride / 1.) 15 min, room temp., 2.) 30 min, room temp., THF

3: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

4: 83 percent / HCl, HOAc

5: CHCl₃ / 2 h

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; diisobutylaluminium deuteride; acetic acid; silver carbonate; In pyridine; diethyl ether; hexane; dichloromethane; chloroform;
DOI:10.1021/jo00004a040