Technology Process of (αR,3R,4S)-3,4-epoxy-3-ethyl-1-<<2-(tert-butyldiphenylsilyl)oxy>-1-phenyl>ethylpiperidine
There total 5 articles about (αR,3R,4S)-3,4-epoxy-3-ethyl-1-<<2-(tert-butyldiphenylsilyl)oxy>-1-phenyl>ethylpiperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / butan-1-ol / 4 h / Heating
2: 79 percent / sodium borohydride / methanol / 0.25 h / 0 °C
3: 71 percent / imidazole / CH2Cl2 / Heating
4: 1.) CF3COOH, 2.) m-chloroperbenzoic acid (MCPBA) / 1.) CH2Cl2, 0 deg C, 10 min, 2.) CH2Cl2, reflux, 24 h
With
1H-imidazole; sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; dichloromethane; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / butan-1-ol / 4 h / Heating
2: 79 percent / sodium borohydride / methanol / 0.25 h / 0 °C
3: 71 percent / imidazole / CH2Cl2 / Heating
4: 1.) CF3COOH, 2.) m-chloroperbenzoic acid (MCPBA) / 1.) CH2Cl2, 0 deg C, 10 min, 2.) CH2Cl2, reflux, 24 h
With
1H-imidazole; sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; dichloromethane; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 percent / imidazole / CH2Cl2 / Heating
2: 1.) CF3COOH, 2.) m-chloroperbenzoic acid (MCPBA) / 1.) CH2Cl2, 0 deg C, 10 min, 2.) CH2Cl2, reflux, 24 h
With
1H-imidazole; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
dichloromethane;
