Technology Process of 2,3-di-O-acetyl-1,6-anhydro-4-O-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)-β-D-glucopyranose
There total 11 articles about 2,3-di-O-acetyl-1,6-anhydro-4-O-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)-β-D-glucopyranose which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: silver trifluoromethanesulfonate / CH2Cl2 / -78 - 20 °C
2: palladium on charcoal / ethanol / 2.5 h
3: pyridine / 12 h / 20 °C
With
pyridine; silver trifluoromethanesulfonate;
palladium on activated charcoal;
In
ethanol; dichloromethane;
1: glycosylation / 2: Hydrogenolysis / 3: Substitution;
DOI:10.1021/ja9627454
- Guidance literature:
-
Multi-step reaction with 8 steps
1: HBr
2: K / methanol / 0.5 h
3: sodium acetate / 0.17 h / Heating
4: 86 percent / potassium hydroxide / tetrahydrofuran / 15 h / Heating
5: bromine / diethyl ether / 1 h
6: silver trifluoromethanesulfonate / CH2Cl2 / -78 - 20 °C
7: palladium on charcoal / ethanol / 2.5 h
8: pyridine / 12 h / 20 °C
With
pyridine; potassium hydroxide; hydrogen bromide; bromine; sodium acetate; silver trifluoromethanesulfonate; potassium;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
1: Acetylation / 2: Deacetylation / 3: Acetylation / 4: benzylation / 5: Bromination / 6: glycosylation / 7: Hydrogenolysis / 8: Substitution;
DOI:10.1021/ja9627454
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium acetate / 0.17 h / Heating
2: 86 percent / potassium hydroxide / tetrahydrofuran / 15 h / Heating
3: bromine / diethyl ether / 1 h
4: silver trifluoromethanesulfonate / CH2Cl2 / -78 - 20 °C
5: palladium on charcoal / ethanol / 2.5 h
6: pyridine / 12 h / 20 °C
With
pyridine; potassium hydroxide; bromine; sodium acetate; silver trifluoromethanesulfonate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
1: Acetylation / 2: benzylation / 3: Bromination / 4: glycosylation / 5: Hydrogenolysis / 6: Substitution;
DOI:10.1021/ja9627454
