C₂₁H₁₆F₄N₄O

Base Information

Chemical Name:C₂₁H₁₆F₄N₄O
CAS No.:1314796-68-3
Molecular Formula:C₂₁H₁₆F₄N₄O
Molecular Weight:416.378
Hs Code.:

C<sub>21</sub>H<sub>16</sub>F<sub>4</sub>N<sub>4</sub>O

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₆F₄N₄O

Chemical Property:

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Technology Process of C₂₁H₁₆F₄N₄O

There total 5 articles about C₂₁H₁₆F₄N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 1314796-68-3
C₂₁H₁₆F₄N₄O

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline / ethanol / 20 h / Reflux

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 18 h / 20 °C / Large scale reaction

4: 1,2-dichloro-ethane; trichlorophosphate / 3 h / 100 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,2-dichloro-ethane; L-proline; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; 1: Friedlaender heterocyclization;
DOI:10.1016/j.bmcl.2011.04.091

Reference yield:

: 1314796-87-6
C₂₁H₁₈F₄N₄O₂

: 1314796-68-3
C₂₁H₁₆F₄N₄O

Guidance literature:: With 1,2-dichloro-ethane; trichlorophosphate; at 100 ℃; for 3h;
DOI:10.1016/j.bmcl.2011.04.091

Reference yield:

: 1314795-64-6
5-(1,8-naphthyridin-2-yl)pentanoic acid

: 1314796-68-3
C₂₁H₁₆F₄N₄O

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 18 h / 20 °C / Large scale reaction

2: 1,2-dichloro-ethane; trichlorophosphate / 3 h / 100 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,2-dichloro-ethane; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.04.091