Technology Process of {(S)-3-[2-((1S,6S)-6-Benzyloxy-3-formyl-1-methyl-cyclohex-2-enyl)-acetyl]-2,2,4-trimethyl-cyclohex-3-enyl}-acetic acid methyl ester
There total 13 articles about {(S)-3-[2-((1S,6S)-6-Benzyloxy-3-formyl-1-methyl-cyclohex-2-enyl)-acetyl]-2,2,4-trimethyl-cyclohex-3-enyl}-acetic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: (COCl)2
3: AgOCOPh
4: DIBAL-H
5: Et3N; DMAP
6: t-BuLi / tetrahydrofuran / -78 - 3 °C
8: TBAF
10: NaClO2
11: TFAA; 2,6-lutidine
12: H3O(1+) / tetrahydrofuran
With
2,6-dimethylpyridine; dmap; sodium chlorite; oxalyl dichloride; oxonium; tetrabutyl ammonium fluoride; tert.-butyl lithium; silver benzoate; diisobutylaluminium hydride; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran;
1: Chlorination / 2: Alkylation / 3: Arndt-Eistert homologation; esterification / 4: Reduction / 5: silylation / 6: Alkylation / 7: Dess-Martin oxidation / 8: desilylation / 9: Dess-Martin oxidation / 10: Oxidation / 11: Pummerer reaction / 12: Hydrolysis / 13: Esterification;
DOI:10.1016/S0040-4039(99)00828-X
- Guidance literature:
-
Multi-step reaction with 9 steps
1: Et3N; DMAP
2: t-BuLi / tetrahydrofuran / -78 - 3 °C
4: TBAF
6: NaClO2
7: TFAA; 2,6-lutidine
8: H3O(1+) / tetrahydrofuran
With
2,6-dimethylpyridine; dmap; sodium chlorite; oxonium; tetrabutyl ammonium fluoride; tert.-butyl lithium; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran;
1: silylation / 2: Alkylation / 3: Dess-Martin oxidation / 4: desilylation / 5: Dess-Martin oxidation / 6: Oxidation / 7: Pummerer reaction / 8: Hydrolysis / 9: Esterification;
DOI:10.1016/S0040-4039(99)00828-X
- Guidance literature:
-
Multi-step reaction with 12 steps
2: AgOCOPh
3: DIBAL-H
4: Et3N; DMAP
5: t-BuLi / tetrahydrofuran / -78 - 3 °C
7: TBAF
9: NaClO2
10: TFAA; 2,6-lutidine
11: H3O(1+) / tetrahydrofuran
With
2,6-dimethylpyridine; dmap; sodium chlorite; oxonium; tetrabutyl ammonium fluoride; tert.-butyl lithium; silver benzoate; diisobutylaluminium hydride; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran;
1: Alkylation / 2: Arndt-Eistert homologation; esterification / 3: Reduction / 4: silylation / 5: Alkylation / 6: Dess-Martin oxidation / 7: desilylation / 8: Dess-Martin oxidation / 9: Oxidation / 10: Pummerer reaction / 11: Hydrolysis / 12: Esterification;
DOI:10.1016/S0040-4039(99)00828-X
