2-nitro-N-(2-phenoxyethyl)aniline

Base Information

• Chemical Name: 2-nitro-N-(2-phenoxyethyl)aniline
• CAS No.: 103748-27-2
• Molecular Formula: C₁₄H₁₄N₂O₃
• Molecular Weight: 258.277
• DSSTox Substance ID: DTXSID601285356
• ChEMBL ID: CHEMBL1485736
• Mol file: 103748-27-2.mol

Synonyms:2-nitro-N-(2-phenoxyethyl)aniline;(2-nitrophenyl)(2-phenoxyethyl)amine;103748-27-2;N-(2-nitrophenyl)-N-(2-phenoxyethyl)amine;Cambridge id 6966135;MLS000677215;CHEMBL1485736;DTXSID601285356;HMS2542E11;MFCD01907049;STK733995;AKOS001749035;2-Nitro-N-(2-phenoxyethyl)benzenamine;SB81816;LS-07666;SMR000271040;CS-0316716;EU-0053013;SR-01000535663;SR-01000535663-1;F1911-3623

Chemical Property of 2-nitro-N-(2-phenoxyethyl)aniline

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 258.10044231
• Heavy Atom Count: 19
• Complexity: 274

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCCNC2=CC=CC=C2[N+](=O)[O-]

Technology Process of 2-nitro-N-(2-phenoxyethyl)aniline

There total 1 articles about 2-nitro-N-(2-phenoxyethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodobenzene (591-50-4) + 2-[(2-nitrophenyl)amino]ethanol (4926-55-0) → 2-nitro-N-(2-phenoxyethyl)aniline (103748-27-2)

Guidance literature:

With triphenyl phosphite; potassium carbonate; Yield given. Multistep reaction; 1.) reflux, 6 h; 2.) reflux, 1 h;

DOI:10.1016/S0040-4020(01)96604-9

Reference yield: 70.0%

acetic anhydride (108-24-7) + 2-nitro-N-(2-phenoxyethyl)aniline (103748-27-2) → N-(2-Nitro-phenyl)-N-(2-phenoxy-ethyl)-acetamide (103748-28-3)

Guidance literature:

With zinc(II) chloride; for 1h; Heating;

DOI:10.1016/S0040-4020(01)96604-9

upstream raw materials:

iodobenzene

2-[(2-nitrophenyl)amino]ethanol

Downstream raw materials:

N-(2-Nitro-phenyl)-N-(2-phenoxy-ethyl)-acetamide