(2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester
CAS No.:115234-83-8
Molecular Formula:C₂₄H₂₅IN₂O₆S
Molecular Weight:596.443
Hs Code.:

(2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

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Chemical Property of (2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

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Technology Process of (2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

There total 5 articles about (2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115234-81-6
benzyl (2S,3R,5R,6R)-3-methyl-3-oxiranyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 115234-83-8
(2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

Guidance literature:: With trifluoroacetic anhydride; sodium iodide; In water; acetonitrile; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90038-9

Reference yield:

: 115252-98-7
benzyl (2S,3R,5R,6R)-3-hydroxymethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 115234-83-8
(2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / DMSO, oxalyl chloride, triethylamine / CH₂Cl₂ / -60 °C

2: ethyl acetate; diethyl ether / 1.) 0 deg C 5 h, 2.) room temp.12 h

3: trifluoroacetic anhydride, NaI / H₂O; acetonitrile / 1 h / Ambient temperature

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; sodium iodide; In diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4020(01)90038-9

Reference yield:

: 115234-74-7
benzyl (2S,3R,5R,6R)-3-formyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 115234-83-8
(2S,3R,5R,6R)-3-(1-Hydroxy-2-iodo-ethyl)-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate; diethyl ether / 1.) 0 deg C 5 h, 2.) room temp.12 h

2: trifluoroacetic anhydride, NaI / H₂O; acetonitrile / 1 h / Ambient temperature

With trifluoroacetic anhydride; sodium iodide; In diethyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4020(01)90038-9