2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide

Base Information

• Chemical Name: 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide
• CAS No.: 110038-96-5
• Molecular Formula: C₃₁H₃₀ClNO₅
• Molecular Weight: 532.036
• Mol file: 110038-96-5.mol

Synonyms:

Chemical Property of 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide

There total 12 articles about 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide (110038-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / NH₄Cl / H₂O; diethyl ether / 24 h / Ambient temperature

2: 57 percent / 1.) borane, 2.) methanol, 3.) HCl gas / 1.) THF, reflux, 3.5 h, 2.) reflux 45 min, 3.) reflux, 15 h;

3: K₂CO₃ / H₂O; CH₂Cl₂; toluene / 1 h

With hydrogenchloride; methanol; borane; potassium carbonate; ammonium chloride; In diethyl ether; dichloromethane; water; toluene;

DOI:10.1002/jhet.5570230641

Reference yield:

vanillin acetate (881-68-5) → 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide (110038-96-5)

Guidance literature:

Multi-step reaction with 10 steps

1: 81 percent / fuming HNO₃ / -20 °C

2: 79 percent / 1.) FeSO₄, aq. HCl, 2.) 15 N ammonium hydroxide; / 90 °C

3: 1.) aq. HCl, NaNO₂, 2.) Cu₂Cl₂; / 1.) water, 0 deg C, 2.) temperature below 5 deg C, 3.) heating on steam bath, 1 h;

4: 89 percent / NaBH₄ / propan-2-ol / 1 h / 70 °C

5: 60 percent / K₂CO₃ / dimethylformamide / 36 h / Ambient temperature

6: 100 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

7: 64 percent / dimethylsulfoxide / 3 h / Ambient temperature

8: 87 percent / aq. 25percent NaOH / ethanol / Heating; overnight

9: SOCl₂ / CH₂Cl₂ / 2.5 h / Heating

10: K₂CO₃ / H₂O; CH₂Cl₂; toluene / 1 h

With copper(I) chloride; hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; nitric acid; potassium carbonate; iron(II) sulfate; sodium nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1002/jhet.5570230641

Reference yield:

α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile (58327-40-5,189683-89-4) → 2-Chloro-N-<2-hydroxy-2-(4-(phenylmethoxy)phenyl)ethyl>-3-methoxy-4-(phenylmethoxy)benzeneacetamide (110038-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / 1.) borane, 2.) methanol, 3.) HCl gas / 1.) THF, reflux, 3.5 h, 2.) reflux 45 min, 3.) reflux, 15 h;

2: K₂CO₃ / H₂O; CH₂Cl₂; toluene / 1 h

With hydrogenchloride; methanol; borane; potassium carbonate; In dichloromethane; water; toluene;

DOI:10.1002/jhet.5570230641

upstream raw materials:

α-(Aminomethyl)-4-(phenylmethoxy)benzenemethanol hydrochloride

p-benzyloxybenzaldehyde

vanillin acetate

α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile

Downstream raw materials:

α-<<<2-<2-Chloro-4-hydroxy-3-methoxy>ethyl>amino>methyl>-4-hydroxybenzenemethanol hydrochloride

6-Chloro-2,3,4,5-tetrahydro-8-hydroxy-1-(4-hydroxyphenyl)-7-methoxy-1H-3-benzazepine hydrochloride

α-<<<2-<2-Chloro-3-methoxy-4-(phenylmethoxy)phenyl>ethyl>amino>ethyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Refernces