2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

Base Information

Chemical Name:2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid
CAS No.:885674-96-4
Molecular Formula:C₃₃H₄₇NO₇Si
Molecular Weight:597.824
Hs Code.:

2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

Synonyms:

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Chemical Property of 2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

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Technology Process of 2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

There total 11 articles about 2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885674-92-0
2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid methyl ester

: 885674-96-4
2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1002/ejoc.200500675

Reference yield:

: 885674-88-4
(S)-5-(4-Methoxy-benzyloxy)-4,4-dimethyl-3-triethylsilanyloxy-pentanal

: 885674-96-4
2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NaHMDS; HMPA / tetrahydrofuran / -78 - 20 °C

2: Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

3: Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 3 h / 20 °C

4: aq. LiOH / tetrahydrofuran / 4 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; sodium hexamethyldisilazane; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Stork-Zhao olefination / 2: Negishi coupling / 3: Sonogashira cross coupling reaction;
DOI:10.1002/ejoc.200500675

Reference yield:

: 885675-21-8
Triethyl-{(S)-1-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-ethyl]-but-3-enyloxy}-silane

: 885674-96-4
2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: O₃; PPh₃ / CH₂Cl₂ / -78 - 20 °C

2: NaHMDS; HMPA / tetrahydrofuran / -78 - 20 °C

3: Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

4: Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 3 h / 20 °C

5: aq. LiOH / tetrahydrofuran / 4 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; sodium hexamethyldisilazane; ozone; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Stork-Zhao olefination / 3: Negishi coupling / 4: Sonogashira cross coupling reaction;
DOI:10.1002/ejoc.200500675