3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

Base Information

Chemical Name:3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester
CAS No.:679406-25-8
Molecular Formula:C₅₆H₇₈N₂O₁₅
Molecular Weight:1019.24
Hs Code.:

3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

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Chemical Property of 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

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Technology Process of 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

There total 2 articles about 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173322-74-2
tautomycin diacid

: 2-aminooxy-N-(3-benzoyl-phenyl)-acetamide

: 679406-25-8
3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

: 679406-26-9
3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

Guidance literature:: With sodium hydroxide; In N,N-dimethyl acetamide; water; at 20 ℃; for 48h; pH=6;
DOI:10.1016/j.tet.2003.12.053

Reference yield:

: 2835-78-1
3-amino benzophenone

: 679406-25-8
3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)-propionic acid 10-(8-{4-[(3-benzoyl-phenylcarbamoyl)-methoxyimino]-3-methyl-pentyl}-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride / CH₂Cl₂ / 1 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

3: 1.6 mg / NaOH / H₂O; N,N-dimethyl-acetamide / 48 h / 20 °C / pH 6

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1016/j.tet.2003.12.053