N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide

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Chemical Name:N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide
CAS No.:677300-22-0
Molecular Formula:C₄₆H₄₄N₄O₅
Molecular Weight:732.879
Hs Code.:

<i>N</i>-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)-butyramide

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Chemical Property of N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide

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Technology Process of N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide

There total 8 articles about N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16754-80-6
4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 677300-22-0
N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / pyridine

2: 86 percent / CrO₃; acetic anhydride; pyridine / CH₂Cl₂

3: 73 percent / n-butyllithium / tetrahydrofuran / 20 °C

4: NH₃ / dioxane / 96 h / 80 °C

5: tetrabutylammonium fluoride / tetrahydrofuran

6: 82 percent / hydrogen / Pd/C / methanol / 5 h

7: pyridine

8: water

9: 93 percent / Li₂CO₃; 2,6-lutidine / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; chromium(VI) oxide; n-butyllithium; tetrabutyl ammonium fluoride; ammonia; water; hydrogen; acetic anhydride; lithium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 3: Wittig reaction;
DOI:10.1081/NCN-120022948

Reference yield:

: (2R,3S,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxymethyl-4-[1-naphthalen-1-yl-meth-(Z)-ylidene]-tetrahydro-furan-3-ol

: 677300-22-0
N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / hydrogen / Pd/C / methanol / 5 h

2: pyridine

3: water

4: 93 percent / Li₂CO₃; 2,6-lutidine / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; water; hydrogen; lithium carbonate; palladium on activated charcoal; In methanol;
DOI:10.1081/NCN-120022948

Reference yield:

: 631897-94-4
4-chloro-7-[3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

: 677300-22-0
N-(7-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-naphthalen-1-ylmethyl-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-butyramide

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / CrO₃; acetic anhydride; pyridine / CH₂Cl₂

2: 73 percent / n-butyllithium / tetrahydrofuran / 20 °C

3: NH₃ / dioxane / 96 h / 80 °C

4: tetrabutylammonium fluoride / tetrahydrofuran

5: 82 percent / hydrogen / Pd/C / methanol / 5 h

6: pyridine

7: water

8: 93 percent / Li₂CO₃; 2,6-lutidine / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; chromium(VI) oxide; n-butyllithium; tetrabutyl ammonium fluoride; ammonia; water; hydrogen; acetic anhydride; lithium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2: Wittig reaction;
DOI:10.1081/NCN-120022948