1-Fluoro-4-(3-nitrophenyl)benzene

Base Information

• Chemical Name: 1-Fluoro-4-(3-nitrophenyl)benzene
• CAS No.: 10540-32-6
• Molecular Formula: C12H8FNO2
• Molecular Weight: 217.19600
• Hs Code.: 2904909090
• Mol file: 10540-32-6.mol

Synonyms:1,1'-Biphenyl,4'-fluoro-3-nitro;4'-fluoro-3-nitrobiphenyl;3-Nitro-4'-fluorobiphenyl;

Chemical Property of 1-Fluoro-4-(3-nitrophenyl)benzene

Chemical Property:

• PSA: 45.82000
• LogP: 3.92410

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Fluoro-4-(3-nitrophenyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Fluoro-4-(3-nitrophenyl)benzene

There total 13 articles about 1-Fluoro-4-(3-nitrophenyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

m-iodonitrobenzene (645-00-1) + 4-fluoroboronic acid (1765-93-1) → 1‐(4‐fluorophenyl)‐3‐nitrobenzene (10540-32-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 120 ℃;

DOI:10.1039/c8ra03697g

Reference yield: 96.0%

m-iodonitrobenzene (645-00-1) + sodium tetrakis(4-fluorophenyl)borate (25776-12-9) → 1‐(4‐fluorophenyl)‐3‐nitrobenzene (10540-32-6)

Guidance literature:

With sodium carbonate; palladium dichloride; In methanol; at 20 ℃; for 0.25h;

DOI:10.1016/j.tet.2010.07.022

Reference yield: 93.0%

m-nitrobenzene boronic acid (13331-27-6) + 1-Bromo-4-fluorobenzene (460-00-4) → 1‐(4‐fluorophenyl)‐3‐nitrobenzene (10540-32-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b00707

upstream raw materials:

fluorobenzene

m-iodonitrobenzene

3'-nitro-[1,1'-biphenyl]-4-yl-amine

m-nitrobromobenzene

Downstream raw materials:

3‐(4‐fluorophenyl)aniline

3,3'''-dinitro-p-quaterphenyl

Refernces

• 1、 Dong, Ying,Jv, Jing-Jing,Li, Yue,Li, Wen-Han,Chen, Yun-Qi,Sun, Qian,Ma, Jian-Ping,Dong, Yu-Bin. "Nickel-metalated porous organic polymer for Suzuki-Miyaura cross-coupling reaction". . p. 20266 - 20272. Retrieved 2019.
• 2、 Zhou, Wen-Jun,Wang, Ke-Hu,Wang, Jin-Xian,Huang, Dan-Feng. "Reusable, polystyrene-resin-supported, palladium-catalyzed, atom-efficient cross-coupling reaction of aryl halides with triarylbismuths". . p. 416 - 419. Retrieved 2010.
• 3、 Chen, Tao,Li, Wen-Qin,Liu, Zheng,Jiang, Wen,Liu, Tian,Yang, Qing,Zhu, Xiao-Lei,Yang, Guang-Fu. "Discovery of Biphenyl-Sulfonamides as Novel β- N-Acetyl- d -Hexosaminidase Inhibitors via Structure-Based Virtual Screening". . p. 12039 - 12047. Retrieved 2021/10/20.
• 4、 Dong, Ying,Jv, Jing-Jing,Wu, Xiao-Wei,Kan, Jing-Lan,Lin, Ting,Dong, Yu-Bin. "A palladium-carbon-connected organometallic framework and its catalytic application". supporting information. p. 14414 - 14417. Retrieved 2019/12/09.