Technology Process of 4-methyl-1-[1-methyl-1-(3,4,5-trimethoxyphenyl)ethyl]-1-[(triisopropylsilyl)ethynyl]-4-(3,4,5-trimethoxyphenyl)pent-2-yn-1-yl methyl carbonate
There total 8 articles about 4-methyl-1-[1-methyl-1-(3,4,5-trimethoxyphenyl)ethyl]-1-[(triisopropylsilyl)ethynyl]-4-(3,4,5-trimethoxyphenyl)pent-2-yn-1-yl methyl carbonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminum hydride / cyclohexane; toluene / 5 h / 0 - 20 °C
1.2: 42 percent / aq. HCl / cyclohexane; toluene / 0 °C
2.1: 51 percent / Jones reagent / acetone / 1 h
3.1: Et3N; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 0 °C
3.2: 36 percent / tetrahydrofuran / 1 h / 0 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
4.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
5.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C
5.2: 96 percent / tetrahydrofuran / -78 °C
6.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C
6.2: 81 percent / tetrahydrofuran / -78 - 20 °C
With
n-butyllithium; jones reagent; sodium hexamethyldisilazane; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; hexane; cyclohexane; acetone; toluene;
DOI:10.1002/ejoc.200700373
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 88 percent / KOtBu / tetrahydrofuran / -30 - 20 °C
2.1: diisobutylaluminum hydride / cyclohexane; toluene / 5 h / 0 - 20 °C
2.2: 42 percent / aq. HCl / cyclohexane; toluene / 0 °C
3.1: 51 percent / Jones reagent / acetone / 1 h
4.1: Et3N; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 0 °C
4.2: 36 percent / tetrahydrofuran / 1 h / 0 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
5.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
6.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C
6.2: 96 percent / tetrahydrofuran / -78 °C
7.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C
7.2: 81 percent / tetrahydrofuran / -78 - 20 °C
With
n-butyllithium; jones reagent; potassium tert-butylate; sodium hexamethyldisilazane; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; hexane; cyclohexane; acetone; toluene;
DOI:10.1002/ejoc.200700373
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 51 percent / Jones reagent / acetone / 1 h
2.1: Et3N; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 0 °C
2.2: 36 percent / tetrahydrofuran / 1 h / 0 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
3.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
4.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C
4.2: 96 percent / tetrahydrofuran / -78 °C
5.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C
5.2: 81 percent / tetrahydrofuran / -78 - 20 °C
With
n-butyllithium; jones reagent; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; hexane; acetone;
DOI:10.1002/ejoc.200700373
