Technology Process of JWH-417
There total 3 articles about JWH-417 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methyl-1-pentylindole;
With
dimethylaluminum chloride;
In
hexane; dichloromethane;
at 0 ℃;
for 0.5h;
Inert atmosphere;
8-Jod-naphthalin-carbonsaeure-(1)-chlorid;
In
hexane; dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.01.038
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
2.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
thionyl chloride; dimethylaluminum chloride;
In
hexane; dichloromethane;
2.1: Friedel-Crafts reaction / 2.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2012.01.038
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodine; potassium iodide / water / 15 h / Reflux
2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
3.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
thionyl chloride; iodine; dimethylaluminum chloride; potassium iodide;
In
hexane; dichloromethane; water;
3.1: Friedel-Crafts reaction / 3.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2012.01.038
