threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Base Information

Chemical Name:threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one
CAS No.:121060-74-0
Molecular Formula:C₂₅H₃₃N₃O₅
Molecular Weight:455.554
Hs Code.:

threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro<piperidine-4,4'(3'H)-quinazolin>-2'(1'H)-one

Synonyms:

Suppliers and Price of threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

There total 5 articles about threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.9%

: 121061-09-4
3'-methyl-1-<2-oxo-2-(3,4,5-trimethoxyphenyl)-1-methylethyl>-spiro-2'(1'H)-one

: 121060-74-0
threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: With L-Selectride; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield:

: 121061-01-6
1-benzyl-6'-chloro-5,6-dihydro-3-iodo-3'-methyl-spiro-2'(1'H)-one

: 121060-74-0
threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98.8 percent / H₂, triethylamine / 10percent Pd-C / H₂O; methanol / 16 h / 40 °C

2: 58.5 percent / triethylamine (TEA), NaI / ethanol / 34 h / Ambient temperature

3: 47.9 percent / 1M L-Selectride / tetrahydrofuran / 1 h / Ambient temperature

With hydrogen; L-Selectride; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 107191-02-6
1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

: 121060-74-0
threo-1-<2-hydroxy-1-methyl-2-(3,4,5-trimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83.4 percent / I₂, NaI, 10percent aq. NaHCO₃ / H₂O; CH₂Cl₂ / 2 h / Ambient temperature

2: 98.8 percent / H₂, triethylamine / 10percent Pd-C / H₂O; methanol / 16 h / 40 °C

3: 58.5 percent / triethylamine (TEA), NaI / ethanol / 34 h / Ambient temperature

4: 47.9 percent / 1M L-Selectride / tetrahydrofuran / 1 h / Ambient temperature

With hydrogen; iodine; L-Selectride; sodium hydrogencarbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;