phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

Base Information

Chemical Name:phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester
CAS No.:943513-74-4
Molecular Formula:C₃₆H₅₈N₅O₈P
Molecular Weight:719.859
Hs Code.:

phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-<i>tert</i>-butyl ester

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Chemical Property of phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

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Technology Process of phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

There total 7 articles about phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 463952-35-4
[(R)-1-hydroxymethyl-3-(4-hydroxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

: 943513-74-4
phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / ethanol; dimethylformamide / 50 °C

2: 100 percent / ammonium formate / Pd/C / methanol / Heating

3: Et₃N / tetrahydrofuran

4: aq. TFA / 20 °C

5: 1H-tetrazole / tetrahydrofuran / 20 °C

6: aq. H₂O₂

With 1H-tetrazole; dihydrogen peroxide; ammonium formate; potassium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.038

Reference yield:

: 849122-54-9
methanesulfonic acid 11-dibenzylaminoundecyl ester

: 943513-74-4
phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / ethanol; dimethylformamide / 50 °C

2: 100 percent / ammonium formate / Pd/C / methanol / Heating

3: Et₃N / tetrahydrofuran

4: aq. TFA / 20 °C

5: 1H-tetrazole / tetrahydrofuran / 20 °C

6: aq. H₂O₂

With 1H-tetrazole; dihydrogen peroxide; ammonium formate; potassium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.038

Reference yield:

: 873302-96-6
{3-[4-(11-dibenzylamino-undecyloxy)-phenyl]-1-hydroxymethyl-1-methyl-propyl}-carbamic acid tert-butyl ester

: 943513-74-4
phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ammonium formate / Pd/C / methanol / Heating

2: Et₃N / tetrahydrofuran

3: aq. TFA / 20 °C

4: 1H-tetrazole / tetrahydrofuran / 20 °C

5: aq. H₂O₂

With 1H-tetrazole; dihydrogen peroxide; ammonium formate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.09.038