Technology Process of 1-(2,4-dinitrophenyl)-3-(2,3-O-isopropylidene-α-D-ribofuranosyl)pyrazole
There total 11 articles about 1-(2,4-dinitrophenyl)-3-(2,3-O-isopropylidene-α-D-ribofuranosyl)pyrazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84 percent / Et3N / benzene / 20 h / Heating
2: 1.) conc. H2SO4 / 1.) acetone, room temperature, 8 h, 2.) pyridine, room temperature, 17 h
With
sulfuric acid; triethylamine;
In
benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) EtMgBr / 1.) THF, 55 deg C, 1 h, 2.) 50 deg C, 1.5 h
2: 1.) 2M HCl, 2.) hydrazine hydrate / 1.) glacial acetic acid, 0.5 h, 2.) acetic acid, reflux 1 h
3: 87 percent / Et3N / benzene / 8 h / Heating
4: 1.) BCl3, 2.) CH3OH / 1.) CH2Cl2, -78 deg C, 5 h, 2.) CH2Cl2, room temperature, overnight
5: conc. H2SO4 / 2 h / Ambient temperature
With
hydrogenchloride; methanol; sulfuric acid; ethylmagnesium bromide; boron trichloride; hydrazine hydrate; triethylamine;
In
benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) EtMgBr / 1.) THF, 1 h, 2.) 24 h
2: 61 percent / manganese dioxide / benzene / 0.5 h / Ambient temperature
3: 91 percent / hydrazine hydrate / ethanol / 0.5 h / Heating
4: 84 percent / Et3N / benzene / 20 h / Heating
5: 1.) conc. H2SO4 / 1.) acetone, room temperature, 8 h, 2.) pyridine, room temperature, 17 h
With
manganese(IV) oxide; sulfuric acid; ethylmagnesium bromide; hydrazine hydrate; triethylamine;
In
ethanol; benzene;
