5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

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Chemical Name:5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one
CAS No.:77737-80-5
Molecular Formula:C₃₂H₂₃N₁₁O₂
Molecular Weight:593.607
Hs Code.:

5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

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Chemical Property of 5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

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Technology Process of 5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

There total 5 articles about 5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 77737-75-8
5-(2-Phenyl-2H-[1,2,3]triazol-4-yl)-3,4-bis-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-dihydro-furan-2-one

: 77737-80-5
5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

Guidance literature:: With sodium hydroxide; at 100 ℃; for 15h;
DOI:10.1016/S0008-6215(00)85622-0

Reference yield:

: 3213-80-7
2-phenyl-1,2,3-triazole-4-carboxaldehyde

: 77737-80-5
5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / 2M Na₂CO₃/KCN / H₂O; dioxane / 1.08 h

2: 20 percent / 2M sulfuric acid/10percent sodium nitrite / acetone / 10 °C

3: 40 percent / a few drops of gl. acetic acid / H₂O; ethanol / 0.03 h / 100 °C

4: 40 percent / 20percent aq. NaOH / 15 h / 100 °C

With potassium cyanide; sodium hydroxide; sulfuric acid; sodium carbonate; acetic acid; sodium nitrite; In 1,4-dioxane; ethanol; water; acetone;
DOI:10.1016/S0008-6215(00)85622-0

Reference yield:

: 69366-72-9
2,3-dioxo-4-(2-phenyl-1,2,3-triazol-4-yl)butano-1,4-lactone

: 77737-80-5
5-[Hydroxy-(2-phenyl-2H-[1,2,3]triazol-4-yl)-methyl]-2-(4-pyrimidin-2-yl-phenyl)-4-[(4-pyrimidin-2-yl-phenyl)-hydrazono]-2,4-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / a few drops of gl. acetic acid / H₂O; ethanol / 0.03 h / 100 °C

2: 40 percent / 20percent aq. NaOH / 15 h / 100 °C

With sodium hydroxide; acetic acid; In ethanol; water;
DOI:10.1016/S0008-6215(00)85622-0