Technology Process of Cbz-Tyr-Pro(4S-NH(Cbz))-Phe-Phe-NH2
There total 8 articles about Cbz-Tyr-Pro(4S-NH(Cbz))-Phe-Phe-NH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Cbz-Tyr-Pro(4(S)-NH(Cbz))-Phe-Phe-OH;
With
4-methyl-morpholine; isobutyl chloroformate;
In
tetrahydrofuran;
at -10 ℃;
for 0.25h;
Inert atmosphere;
With
ammonium hydroxide;
In
tetrahydrofuran;
at -10 - 20 ℃;
for 3.25h;
Inert atmosphere;
DOI:10.1021/jm201402v
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere
2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere
3.2: pH 3 / Inert atmosphere
4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere
4.2: 3.25 h / -10 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201402v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere
2.2: pH 3 / Inert atmosphere
3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere
3.2: 3.25 h / -10 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm201402v
