4-isobutylcinnamic acid chloride

Base Information

• Chemical Name: 4-isobutylcinnamic acid chloride
• CAS No.: 945387-41-7
• Molecular Formula: C₁₃H₁₅ClO
• Molecular Weight: 222.715
• Mol file: 945387-41-7.mol

Synonyms:

Chemical Property of 4-isobutylcinnamic acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-isobutylcinnamic acid chloride

There total 5 articles about 4-isobutylcinnamic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-isobutylcinnamic acid (66734-95-0) → 4-isobutylcinnamic acid chloride (945387-41-7)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.666667h;

DOI:10.1021/jm00394a032

Reference yield:

4-(2-methyl-1-propyl)benzaldehyde (40150-98-9) → 4-isobutylcinnamic acid chloride (945387-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / morpholine / 2 h / Heating

2: oxalyl chloride, DMF / CH₂Cl₂ / 0.67 h

With morpholine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm00394a032

Reference yield:

1-(4-isobutyl-phenyl)-ethanone (38861-78-8) → 4-isobutylcinnamic acid chloride (945387-41-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 38 percent / aq. sodium hypochlorite / 12 h / Heating

2: borane / tetrahydrofuran / 3 h / Ambient temperature

3: 89 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h

4: 86 percent / morpholine / 2 h / Heating

5: oxalyl chloride, DMF / CH₂Cl₂ / 0.67 h

With morpholine; sodium hypochlorite; oxalyl dichloride; borane; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00394a032

upstream raw materials:

4-isobutylcinnamic acid

4-(2-methyl-1-propyl)benzaldehyde

1-(4-isobutyl-phenyl)-ethanone

4-isobutylbenzoic acid