1-(4-(3-{4-(1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-ylmethoxy)phenyl}-4,5-dihydroisoxazol-5-yl)butyl)-2-nitroimidazole

Base Information

• Chemical Name: 1-(4-(3-{4-(1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-ylmethoxy)phenyl}-4,5-dihydroisoxazol-5-yl)butyl)-2-nitroimidazole
• CAS No.: 143334-77-4
• Molecular Formula: C₁₉H₃₀B₁₀N₄O₄
• Molecular Weight: 486.582
• Mol file: 143334-77-4.mol

Synonyms:

Chemical Property of 1-(4-(3-{4-(1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-ylmethoxy)phenyl}-4,5-dihydroisoxazol-5-yl)butyl)-2-nitroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(3-{4-(1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-ylmethoxy)phenyl}-4,5-dihydroisoxazol-5-yl)butyl)-2-nitroimidazole

There total 1 articles about 1-(4-(3-{4-(1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-ylmethoxy)phenyl}-4,5-dihydroisoxazol-5-yl)butyl)-2-nitroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-{4-(hydroxyiminomethyl)phenoxymethyl}-1,2-dicarba-closo-dodecaborane(12) + 1-(CHCH(CH2)4)-2-nitroimidazole (143346-29-6) → 1-(4-(3-{4-(1,2-dicarba-closo-dodecaboran(12)-1-ylmethoxy)phenyl}-4,5-dihydroisoxazol-5-yl)butyl)-2-nitroimidazole (143334-77-4) + 4-(1,2-dicarba-closo-dodecaboran(12)-1-ylmethoxy)benzonitrile N-oxide (143334-76-3)

Guidance literature:

With NaOCl; H₂O; In dichloromethane; vigorous stirring of the oxime and the azole in CH2Cl2 together with aq. NaOCl for 18 h, addn. of further aq. NaOCl, stirring for a further 1.5 h; washing (H2O), evapn., chromy. of the residue (silica gel, pentane-CH2Cl2 1:1, then CH2Cl2, then ethyl acetate), from the first fraction: the N-oxide, from the third fraction: the imidazole;

DOI:10.1039/P19940000203

upstream raw materials:

1-(CHCH(CH₂)4)-2-nitroimidazole