Technology Process of [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[1-(6,2'-dimethoxy-biphenyl-2-yl)-meth-(E)-ylidene]-amine
There total 12 articles about [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[1-(6,2'-dimethoxy-biphenyl-2-yl)-meth-(E)-ylidene]-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium superoxide;
18-crown-6 ether;
In
diethyl ether;
Ambient temperature;
DOI:10.1021/ja00289a023
- Guidance literature:
-
Multi-step reaction with 8 steps
1: oxalyl chloride / CH2Cl2 / 14 h
2: 30 percent NH4OH
3: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux
4: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h
5: 1 M DIBAL / diethyl ether / Ambient temperature
6: tetrahydrofuran / 12 h / Ambient temperature
7: N-chlorosuccinimide / CH2Cl2 / 0.25 h
8: potassium superoxide / 18-crown-6 / diethyl ether / Ambient temperature
With
potassium superoxide; ammonium hydroxide; N-chloro-succinimide; oxalyl dichloride; triethyloxonium fluoroborate; diisobutylaluminium hydride; magnesium;
18-crown-6 ether;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00289a023
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux
2: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h
3: 1 M DIBAL / diethyl ether / Ambient temperature
4: tetrahydrofuran / 12 h / Ambient temperature
5: N-chlorosuccinimide / CH2Cl2 / 0.25 h
6: potassium superoxide / 18-crown-6 / diethyl ether / Ambient temperature
With
potassium superoxide; N-chloro-succinimide; triethyloxonium fluoroborate; diisobutylaluminium hydride; magnesium;
18-crown-6 ether;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00289a023
