2-Iodo-4-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Iodo-4-methoxybenzaldehyde
• CAS No.: 105469-13-4
• Molecular Formula: C8H7IO2
• Molecular Weight: 262.047
• DSSTox Substance ID: DTXSID50457686
• Nikkaji Number: J2.046.745B
• Wikidata: Q82280628
• Mol file: 105469-13-4.mol

Synonyms:2-Iodo-4-methoxybenzaldehyde;105469-13-4;2-iodo-4-methoxy-benzaldehyde;Benzaldehyde, 2-iodo-4-methoxy-;SCHEMBL6248063;DTXSID50457686;HYWMSRPGGMIKKZ-UHFFFAOYSA-N;MFCD18452131;AKOS015969572;BS-14238;CS-0150498;D82574

Chemical Property of 2-Iodo-4-methoxybenzaldehyde

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 261.94908
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C=O)I

Technology Process of 2-Iodo-4-methoxybenzaldehyde

There total 13 articles about 2-Iodo-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C10H12INO2 (1228657-93-9) → 2-iodo-4-methoxybenzaldehyde (105469-13-4)

Guidance literature:

With zirconocene dichloride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 20 ℃; for 0.133333h; Inert atmosphere;

DOI:10.1021/ol403183a

Reference yield: 89.0%

→ 2-iodo-4-methoxybenzaldehyde (105469-13-4)

Guidance literature:

Reference yield: 46.0%

4,4-dimethyl-2-(2-iodo-4-methoxyphenyl)-2-oxazoline → 2-iodo-4-methoxybenzaldehyde (105469-13-4)

Guidance literature:

4,4-dimethyl-2-(2-iodo-4-methoxyphenyl)-2-oxazoline; With methyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane; at 0 ℃; for 1h; Further stages; Inert atmosphere;

DOI:10.1002/anie.200902884

upstream raw materials:

p-Anisaldehyde dimethyl acetal

4-hydroxy-2-iodobenzaldehyde

dimethyl sulfate

C-<2-Jod-4-methoxy-phenyl>-N-<4-dimethylamino-phenyl>-nitron

Downstream raw materials:

2-iodo-4-methoxybenzoic acid

C₃₀H₂₆I₂N₂O₄

4-methoxy-2-(2-trimethylsilylethynyl)benzaldehyde

(E)-3-(2-Iodo-4-methoxy-phenyl)-acrylic acid ethyl ester